Submitted articles

2. Tuning Reactivity of Micellar Nanoreactors by Precise Adjustments of the Amphiphiles and Substrates Hydrophobicity. Tevet, Shahar; Wagle, Shreyas Shankar; Slor, Gadi; Amir, Roey J. (2021) ChemRxiv. Preprint. https://doi.org/10.26434/chemrxiv.14706009.v1 

1. Dendron-Polymer Hybrids as Tailorable Coronae of Single-Walled Carbon Nanotube. Wulf, Verena; Slor, Gadi; Rathee, Parul; Amir, Roey J.; Bisker, Gili. (2021) ChemRxiv. Preprint. https://doi.org/10.26434/chemrxiv.14452785.v1 

Articles in peer-reviewed journals

42. Order from disorder with intrinsically disordered peptide amphiphiles. Jacoby, Guy; Segal Asher, Merav; Ehm, Tamara; Abutbul Ionita, Inbal; Shinar, Hila; Azoulay-Ginsburg, Salome; Danino, Dganit; Kozlov, Michael M.; Amir, Roey J.; Beck, Roy.   J. Am. Chem. Soc. (2021) 143(30): 11879–11888.

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41. Judging Enzyme-Responsive Micelles by Their Covers: Direct Comparison of Dendritic Amphiphiles with Different Hydrophilic Blocks. Slor, Gadi; Olea, Alis R.; Pujals, Sílvia; Tigrine, Ali; De La Rosa, Victor R.;  Hoogenboom, Richard; Lorenzo Albertazzi, Lorenzo*; Amir, Roey J.* Biomacromolecules (2021) 22(3): 1197–1210.

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39. Real-Time Ratiometric Imaging of Micelles Assembly State in a Microfluidic Cancer-on-a-Chip. Feiner-Gracia, Natalia; Glinkowska Mares, Adrianna; Buzhor, Marina; Rodriguez-Trujillo, Romen; Samitier Marti, josep; Amir, Roey J.*, Pujals, Silvia; Albertazzi, Lorenzo* ACS Appl. Bio Mater. (2021), 4 (1): 669–681.

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38. Architectural Change of the Shell-Forming Block from Linear to V-Shaped Accelerates Micellar Disassembly, but Slows the Complete Enzymatic Degradation of the Amphiphiles. Segal, Merav; Ozery, Lihi; Slor, Gadi; Wagle, Shreyas Shankar; Ehm, Tamara; Beck, Roy;  Amir, Roey J.* Biomacromolecules (2020), 21(10) 4076–4086.

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37. Utilizing Self-Immolative ATRP Initiators To Prepare StimuliResponsive Polymeric Films from Nonresponsive Polymers. Peles-Strahl, Leigh; Sasson, Revital; Slor, Gadi; Edelstein-Pardo, Nicole; Dahan, Adi*; Amir, Roey J.* Macromolecules (2019), 52, 3268-3277.

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35. Tuning the molecular weight of polymeric amphiphiles as a tool to access micelles with a wide range of enzymatic degradation rates. Slor, Gadi; Papo, Nitsan; Hananel, Uri; Amir, Roey J.* Chemical Communications (2018), 54, 6875-6878. This article is part of the themed collection: 2018 Emerging Investigators

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34. A microfluidic chip containing multiple 3D nanofibrous scaffolds for culturing human pluripotent stem cells. Wertheim, Lior; Shapira, Assaf; Amir, Roey J.; Dvir, Tal* Nanotechnology (2018), 29, 13LT01.

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33. Micellar stability in biological media dictates internalization in living cells. Feiner-Gracia, Natalia; Buzhor Marina; Fuentes, Edgar; Pujals, Silvia; Amir, Roey J.*; Albertazzi, Lorenzo* Journal of the American Chemical Society (2017), 139, 16677-16687. Highlighted in JACS Spotlight: Synthesis Meets Biology in New Dendron Research StudySynthesis Meets Biology in New Dendron Research Study. Journal of the American Chemical Society (2017), 139 (48), pp 17199-17200.

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32. Reversible dimerization of polymeric amphiphiles acts as a molecular switch of enzymatic degradabilityRosenbaum, Ido; Avinery, Ram; Harnoy, Assaf J.; Slor, Gadi; Tirosh, Einat; Hananel, Uri; Beck, Roy; Amir, Roey J.* Biomacromolecules (2017), 18, 3457-3468.

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31. Modular synthetic approach for adjusting the disassembly rates of enzyme-responsive polymeric micelles. Harnoy, Assaf J.; Buzhor Marina; Tirosh, Einat; Shaharabani, Rona;  Beck, Roy; Amir, Roey J.* Biomacromolecules (2017), 18, 1218-1228.

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30. Molecular precision and enzymatic degradation: from readily to undegradable polymeric micelles by minor structural changes. Segal, Merav; Avinery, Ram; Buzhor Marina; Shaharabani, Rona; Harnoy, Assaf J.; Tirosh, Einat; Beck, Roy; Amir, Roey J.* Journal of the American Chemical Society (2017), 139, 803-810.

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29. The effect of photoisomerization on the enzymatic hydrolysis of polymeric micelles bearing photo-responsive azobenzene groups at their cores. Harnoy, Assaf. J.; Slor, Gadi; Tirosh, Einat; Amir, Roey J.* Organic & Biomolecular Chemistry (2016), 14, 5813-5819. This article is part of themed collection: New Talent 2016

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28. Fluorinated Smart Micelles as Enzyme-responsive Probes for 19F-Magnetic Resonance. Buzhor, Marina; Avram, Liat; Frish, Limor; Cohen, Yoram; Amir, Roey J.* Journal of Materials Chemistry B (2016), 4, 3037-3042. This article is part of themed collections: Emerging Investigators 2016: Novel design strategies for new functional materials and 2016 Journal of Materials Chemistry B Hot Papers

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26. Supramolecular translation of enzymatically triggered disassembly of micelles into tunable fluorescent responses. Buzhor, Marina; Harnoy, Assaf J.; Tirosh, Einat; Barak, Ayana; Schwartz, Tal; Amir, Roey J.* Chemistry - A European Journal (2015), 21, 15633–15638.

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25. Encapsulation and covalent binding of molecular payload in enzymatically activated micellar nanocarriers. Rosenbaum, Ido; Harnoy, Assaf J.; Tirosh, Einat; Buzhor Marina; Segal, Merav; Frid, Liat; Shaharabani, Rona; Avinery, Ram; Beck, Roy; Amir, Roey J.* Journal of the American Chemical Society (2015), 137, 2276-2284.

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24. Conjugated oligomers incorporating azulene building blocks - seven- vs. five-​membered ring connectivity. Amir, Elizabeth; Murai, Masahito; Amir, Roey J.; Cowart, John S. Jr.; Chabinyc, Michael L.; Hawker, Craig J. Chemical Science (2014), 5(11),4483-4489.

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23. Breakdown of Interference Rules in Azulene, a Nonalternant Hydrocarbon. Xia, Jianlong; Capozzi, Brian; Wei, Sujun; Strange, Mikkel; Batra, Arunabh; Moreno, Jose R.; Amir, Roey J.; Amir, Elizabeth; Solomon, Gemma C.; Venkataraman, Latha, Campos, Luis, M. Nano Letters (2014), 14, 2941-2945. Highlighted in Nature Nanotechnology: Azulene challenges the rules.

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22. Enzyme-Responsive Amphiphilic PEG-Dendron Hybrids and Their Assembly into Smart Micellar Nanocarriers. Harnoy, Assaf J.; Rosenbaum, Ido; Tirosh, Einat; Ebenstein, Yuval; Shaharabani, Rona; Beck, Roy; Amir, Roey J.* Journal of the American Chemical Society (2014), 136, 7531-7534.

Highlighted in JACS Spotlight: Enzymes Break It Down for Drug Delivery.

Journal of the American Chemical Society (2014), 136 (21), pp 7517–7518.

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21. Enhanced Bioactivity of Internally Functionalized Cationic Dendrimers with PEG Cores.  Albertazzi, Lorenzo; Mickler, Frauke M.; Pavan, Giovanni M.; Salomone, Fabrizio; Bardi, Giuseppe; Panniello, Mariangela; Amir, Elizabeth; Kang, Taegon; Killops, Kato L.; Brauchle, Christoph; Amir, Roey J.*; Hawker, Craig J.* Biomacromolecules (2012), 13, 4089-4097.

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20. Azulene-based conjugated polymers: unique seven-membered ring connectivity leading to stimuli responsiveness. Murai, Masahito; Amir, Elizabeth; Amir, Roey J.; Hawker, Craig J. Chemical Science (2012), 3 (9), 2721-2725.

19. Biodegradable, multi-layered coatings for controlled release of small molecules. Amir, Elizabeth; Antoni, Per; Campos, Luis M.; Damiron,Denis; Gupta, Nalini; Amir, Roey J.; Pesika, Noshir; Drockenmuller, Eric; Hawker, Craig J. Chemical Communications (2012), 48, 4833-4835.

18. Effect of precursor chain-length on the formation and stability of poly(ethylene glycol)-based supramolecular star polymers. Gadwal, Ikhlas; De, Swati; Stuparu, Mihaiela C.; Jang, Se Gyu; Amir, Roey J.; Khan, Anzar. Journal of Polymer Science, Part A: Polymer Chemistry (2012), 50(12), 2415-2420.

17. Supramolecular star polymers with compositional heterogeity. Gadwal, Ikhlas; De, Swati; Stuparu, Mihaiela C.; Amir, Roey J.; Jang, Se Gyu; Khan, Anzar. Journal of Polymer Science, Part A: Polymer Chemistry (2012), 50(9), 1844-1850.

16. Encoded Dendrimers with Defined Chiral Composition via 'Click' Reaction of Enantiopure Building Blocks. Yeniad, Bahar; Naik, Hemantkumar; Amir, Roey J.; Koning, Cor E.; Hawker, Craig J.; Andreas, Heise. Chemical Communications (2011), 47, 9870-9872.

15. Stimuli-Responsive Azulene-Based Conjugated Oligomers with Polyaniline-like Properties. Amir, Elizabeth; Amir, Roey J.; Campos, Luis M.; Hawker, Craig J. Journal of the American Chemical Society (2011), 133 (26), 10046-10049.

14. Multi-functional Trackable Dendritic Scaffolds and Delivery Agents. Amir, Roey J.; Albertazzi, Lorenzo; Willis, Jenny; Kang, Taegon; Khan, Anzar; Hawker, Craig J. Angewandte Chemie, International Edition (2011), 50 (15), 3425-3429.

13. Rapid Synthesis of Block and Cyclic Copolymers via Click Chemistry in the Presence of Copper Nanoparticles. Pressly, Eric D.; Amir, Roey J.; Hawker, Craig J.  Journal of Polymer Science Part A: Polymer Chemistry (2011), 49 (3), 814-819.

12. Facile Access to Internally Functionalized Dendrimers through Efficient and Orthogonal Click Reactions. Kang, Taegon; Amir, Roey J.; Khan, Anzar; Ohshimizu, Kaoru; Hunt, Jasmine N.; Sivanandan, Kulandaivelu; Montanez, Maria I.; Malkoch, Michael; Ueda, Mitsuru; Hawker, Craig J.  Chemical Communications (2010), 46 (9), 1556-1558.

11. Enzymatically Triggered Self-Assembly of Block Copolymers. Amir, Roey, J.*; Zhong, Sheng; Pochan, Darrin, J.; Hawker, Craig, J.* Journal of the American Chemical Society (2009), 131 (39), 13949-13951.

10. Free Radical Polymers with Tunable and Selective Bio- and Chemical Degradability. Paulusse, Jos M.J.; Amir, Roey J.; Evans, Richard A.; Hawker, Craig J.  Journal of the American Chemical Society (2009), 131 (28), 9805-9812.

9. Substituent-Dependent Disassembly of Self-Immolative Dendrimers. Perry, Rotem; Amir, Roey J.; Shabat, Doron. New Journal of Chemistry (2007), 31 (7), 1307-1321.

8. Receiver-Amplifier, Self-Immolative Dendritic Device. Amir, Roey J.; Danieli, Eyal; Shabat, Doron. Chemistry - A European Journal (2007), 13 (3), 812-821.

7. Domino Dendrimers. Amir, Roey J.; Shabat, Doron. In Polymer Therapeutics: Polymers as Drugs, Conjugates and Gene Delivery Systems. Ed. : Ruth Duncan, Helmut Ringsdorf and Ronit Satchi-Fainaro. Advances in Polymer Sciences (2006), 192, 59-94.

6. Prodrug Activation Gated by a Molecular OR Logic Trigger. Amir, Roey J.; Popkov, Mikhail; Lerner, Richard A.; Barbas III, Carlos F.; Shabat, Doron.  Angewandte Chemie, International Edition (2005), 44 (28), 4378-4381.

5. Some New Aspects of Dendrimer Applications. Flomenbom, Ophir; Amir, Roey J.; Shabat, Doron; Klafter, Joseph. Journal of Luminescence (2005), 111(4), 315-325.

4. Chemical Adaptor Systems. Shabat, Doron; Amir, Roey J.; Gopin, Anna; Pessah, Neta; Shamis, Marina. Chemistry - A European Journal (2004), 10(11), 2626-2634. 

3. Self-Immolative Dendrimer Biodegradability by Multi-Enzymatic Triggering. Amir, Roey J.; Shabat, Doron. Chemical Communications (2004), 14, 1614-1615.

2. Self-Immolative Dendrimers. Amir, Roey J.; Pessah, Neta; Shamis, Marina; Shabat, Doron. Angewandte Chemie, International Edition (2003), 42(37), 4494-4499.

1. Hydrolytically Activated Etoposide Prodrugs Inhibit MDR-1 Function and Eradicate Established MDR-1 Multidrug-Resistant T-cell Leukemia. Schroeder, Ulrike; Bernt, Kathrin M.; Lange, Bjoern; Wenkel, Jens; Jikai, Jiang; Shabat, Doron; Amir, Roey; Huebener, Nicole; Niethammer, Andreas G.; Hagemeier, Christian; Wiebusch, Lueder; Gaedicke, Gerhard; Wrasidlo, Wolfgang; Reisfeld, Ralph A.; Lode, Holger N. Blood (2003), 102 (1), 246-253.

Book chapters

3. Self-decomposing Dendrimers. Frid. Liat; Amir, Roey J.*

In Encyclopedia of Polymeric Nanomaterials, ed. Kobayashi, S and Müllen, K., Springer Berlin Heidelberg (2014).

2. Dendrimer - Based Devices: Antennae and Amplifiers. Flomenbom, Ophir; Amir, Roey J.; Shabat, Doron; Klafter, Joseph. 
In Energy Harvesting Materials, ed. D.L. Andrews, World Scientific Publishing Co, Singapore (2005), 245-279.

1. Medicinal Potential of Catalytic Antibodies. Amir, Roey; Shabat, Doron.
In Catalytic Antibodies, ed. E. Keinan, Wiley-VCH Verlag GmbH & Co. Germany (2005), 284-303.

Patent applications

5. Delivery system in micellar form having modular spectral response based on enzyme-responsive amphiphilic PEG-dendron hybrid polymers.

Amir, Roey J.; Buzhor, Marina; Harnoy, Assaf Josef.

Current Assignee: Ramot At Tel Aviv University Ltd

US10869939B2 

4. AGROCHEMICAL DELIVERY SYSTEM BASED ON ENZYME- OR pH- RESPONSIVE AMPHIPHILIC PEG-DENDRON HYBRIDS.

Amir, Roey J.; Buzhor, Marina; Harnoy, Assaf Josef; Rosenbaum, Ido; Frid, Liat.

Current Assignee: Ramot At Tel Aviv University Ltd

US20170245492A1 

3. Micelar delivery system based on enzyme-responsive amphiphilic peg-dendron hybrid. 

Amir, Roey J.; Buzhor, Marina; Harnoy, Assaf Josef; Rosenbaum, Ido; Frid, Liat.

Current Assignee: Ramot At Tel Aviv University Ltd

US20170348430A1 

2. Multi-Triggered Self-Immolative Dendritic Compounds.
Amir, Roey J.; Shabat, Doron. 

Current Assignee: Ramot At Tel Aviv University Ltd
US20060269480A1 

1. Self-Immolative Dendrimers Releasing Many Active Moieties Upon a Single Activating Event.
Shabat, Doron; List, Benjamin; Amir, Roey Jacob; Shamis, Marina; Pessah, Neta.
US20050271615A1